Contrave (Bupropion/Naltrexone Combination) For Effective Weight Loss

Contrave for weight loss - Heal n Cure Medical wellness Center

Contrave for weight loss - Heal n Cure Medical wellness Center

Losing weight can often feel like an uphill battle, one that many of us know all too well. We understand the frustration and the endless search for something that actually delivers on its promise. That’s why we’re thrilled to introduce you to CONTRAVE, a game-changer in weight management approved by the FDA. This powerful combination of bupropion and naltrexone is here to support your journey.

Through this article, let’s unpack how CONTRAVE operates and determine if it could be the missing piece in your puzzle towards achieving a healthier self. Let’s dive into this together!

Key Takeaways

  • Contrave combines naltrexone and bupropion to help control hunger and cravings, making it easier to lose weight.
  • The FDA approves Contrave for adults who are overweight with a related health issue like diabetes or high blood pressure.
  • Studies show that people taking Contrave can lose about 12% of their body weight when they also eat right and exercise.
  • Some common side effects include nausea, headaches, and feeling jittery, but these usually go away as your body adjusts.
  • Before starting Contrave, talk to your doctor about its safety for you, especially if you’re taking other medicines or have health concerns.

Understanding CONTRAVE


CONTRAVE is a medicine that combines two drugs, naltrexone and bupropion. This mix is for people who want to lose weight. Doctors say you should also eat less, move more, and make other healthy changes while taking it.

The Food and Drug Administration (FDA) says it’s okay for folks who are overweight and have at least one health problem.

This pill slowly releases its ingredients to work on the brain’s hunger signals. We don’t know all the ways CONTRAVE helps with weight loss. But studies show that many people lose weight safely when they follow their doctor’s advice with this medication.

How does CONTRAVE work?

CONTRAVE uses a mix of two main ingredients, bupropion and naltrexone. Bupropion helps lessen your appetite while naltrexone works on controlling cravings. Together, these components target the parts of your brain that make you feel hungry or crave certain foods.

We understand this combo might sound complex, but it’s all about teamwork. These drugs team up to help you eat less and stick to healthier choices without feeling like you’re missing out.

Our bodies respond to food with feelings of pleasure, thanks to certain chemicals in our brains. CONTRAVE lightly steps in and changes how these chemicals act, which helps reduce hunger pangs and the urge to reach for snacks every so often.

It’s kind of like having a gentle guardian for your dieting goals, supporting you as part of a bigger plan that includes eating right and moving more. With doctor approval and alongside other lifestyle changes, taking CONTRAVE leads many towards their weight loss journey with confidence.

The Science Behind CONTRAVE

The science behind CONTRAVE is all about how it tricks the brain into feeling full. It combines two medicines, one that targets hunger signals and another that works on pleasure parts of the brain related to food.

CONTRAVE’s approach to weight loss

CONTRAVE uses a duo of medicines, bupropion and naltrexone, for cutting down hunger and managing cravings. This pair works on your brain’s reward system that deals with pleasure from eating and addiction to food. It changes how the brain thinks about food, making you want less of it and feel fuller sooner.

This unique mix helps control impulsive eating by acting on two parts of the brain involved in weight regulation. Bupropion lifts mood and deals with depression, often linked to overeating.

Naltrexone reduces the pull towards food by dulling the satisfaction one gets from eating too much or unhealthy foods. Together, they form a powerful team in helping adults who are obese see progress in their weight loss journeys without relying solely on diet or physical activity changes.

The role of the brain in weight management

The brain plays a key part in managing weight. It uses areas like the hypothalamus to control hunger and energy use. The combination found in Contrave acts on these parts of the brain, helping reduce appetite and cravings.

This action is crucial for losing weight and keeping it off.

Preclinical studies show that naltrexone/bupropion works well in these brain regions for weight management. Bupropion alone can lead to modest weight loss by affecting neurotransmitters involved in mood and appetite regulation.

Together with naltrexone, this duo makes it easier to stick to reduced-calorie diets by controlling how much you want to eat. This approach focuses not just on the body but also on the mind’s role in achieving healthier weights.

Is CONTRAVE Right for Me?

Deciding if CONTRAVE fits your needs involves looking at your health and weight goals. A doctor can help figure out if it’s a good match for you after checking things like your body fat percentage and any health issues you might have.

Criteria for using CONTRAVE

To use CONTRAVE, adults must have obesity with a body mass index (BMI) of 30 kg/m^2 or higher. People with a BMI of 27 kg/m^2 or more who also face health issues like type 2 diabetes, high cholesterol, or high blood pressure can consider it too.

It’s crucial to combine the medication with healthy eating and physical activity for the best results.

A healthcare professional should guide anyone interested in starting CONTRAVE. They will review your medical history to ensure it’s safe for you to take this medication. Remember, it’s not suitable for everyone—especially those allergic to its ingredients or pregnant women.

Side effects are possible, so weigh these against the benefits with your doctor’s help before deciding.

Personal Weight Loss Assessment

Deciding if CONTRAVE is right for you involves looking at your own weight loss journey. We need to see if you’re overweight and have a medical issue like diabetes. This step is important for safety and success.

First, we check your health history and your current medications. This helps us avoid bad reactions with CONTRAVE. Your goals play a big part too. Together, we create a plan that fits you best, making sure CONTRAVE can be part of your path to losing weight safely and effectively.

Efficacy of CONTRAVE in Clinical Trials

Research shows CONTRAVE works well in scientific tests. People lost more weight with it than without.

Overview of clinical studies

Clinical trials have shown that the combination of naltrexone and bupropion can help people lose weight. These studies included changes in lifestyle like diet and exercise. We learned from the COR trial series that this mix is good for long-term weight management.

Another study found that taking both drugs together works better than taking each one by itself.

We also saw that people who stick with their treatment plan can see real benefits. A special look at four major tests found certain genes might make some folks more likely to lose weight on this program.

Safety was a big focus too, with one test checking how safe it is for overweight and obese patients to use these medicines together. This all helps us understand just how effective naltrexone-bupropion can be for losing weight when you add healthy habits into your routine.

Results from the studies

Studies showed that combining naltrexone SR and bupropion SR, known as Contrave, helps with weight management. This mix works better than either drug alone for losing weight. People who added a balanced diet and exercise to Contrave treatment lost about 12% of their body weight in 16 weeks.

Clinical trials also found this combination safe for long-term use in managing weight.

Extended-release naltrexone/bupropion led to more weight loss than a dummy pill in four studies over 56 weeks. These findings support the idea that careful eating and regular physical activity—along with Contrave—can make a big difference in one’s health journey.

Safety and Tolerability of CONTRAVE

When starting CONTRAVE, some people might feel sick, get headaches, or have a hard time sleeping. Yet, knowing what to expect can help you prepare. Dive deeper to learn more about staying safe while taking this weight loss aid.

Common side effects

Some people taking CONTRAVE experience restlessness, agitation, trembling hands, trouble walking straight, spinning feeling, and lightheadedness. These are some of the side effects related to bupropion in Contrave.

Also common are feelings of pins and needles, dry mouth, stopped-up bowels, and strange taste sensations. These problems often happen more as the dose goes up.

It’s good to know these facts so you can watch for changes and talk with your doctor about what’s happening. Your health is important and knowing what might come up helps keep surprises at bay while working towards your weight loss goals.

Precautions and drug interactions

We need to take care with Contrave because it has a boxed warning. This means it can cause serious thoughts of suicide and other bad mood reactions in some people taking bupropion.

If you’ve ever had seizures, be extra cautious. Bupropion raises the risk of having one, especially if you take more than advised.

Also, mixing Contrave with other weight loss aids isn’t recommended until we know more about how they work together. It’s important to watch out for side effects that need a doctor right away, which includes our medicine mix not being safe for everyone.

Tell your doctor about all the medicines you use—prescription drugs, over-the-counter aids, and even stuff like cold medicines or painkillers—because they might interact poorly with Contrave.

What To Expect When Starting CONTRAVE

Starting CONTRAVE is a big step in your journey towards health and wellness. You’ll start with a lower dose to help your body adjust, then slowly increase it as directed by Dr. Meena Malhotra or another expert at Heal n Cure Medical Wellness Center.

This approach helps reduce the chance of side effects like nausea, trouble sleeping, or constipation.

You might feel some side effects as your body gets used to the medication. Feeling sick, having headaches, or feeling jittery are common at first but usually go away over time. Keep an eye on how you feel and talk to your doctor about any concerns.

Remember, sticking to a healthy diet and exercise plan boosts your chances of success with CONTRAVE for weight loss.


Contrave brings together naltrexone and bupropion for a powerful way to lose weight. This combination, backed by diet and exercise, has shown real results. It works with your brain to control hunger and cravings.

People have shared their success stories, proving it’s effective. With its FDA approval, you can trust Contrave as part of your weight loss journey.


1. What is Contrave, and how does it help with weight loss?

Contrave combines two medications, Bupropion and Naltrexone, used together to manage weight. This combination works by targeting the root causes of hunger and cravings, making it easier for people to lose weight as part of a comprehensive weight loss program.

2. Can anyone use Contrave for losing weight?

Not everyone can safely use Contrave. It’s not recommended for individuals with uncontrolled high blood pressure, seizures, or those who are pregnant or breastfeeding. Also, if you have a history of opioid dependence or use other forms of bupropion like Wellbutrin SR or Zyban, you should avoid it.

3. Are there any side effects I should worry about when taking Contrave?

Yes, like all medications, Contrave can cause side effects such as nausea, constipation, headache, vomiting,dizziness,and dry mouth.More serious risks include seizures,blood pressure changes,and increased risk of suicidal thoughts.Those with a history of bipolar disorder,eating disorders,such as bulimia,and certain medical conditions should exercise caution.

4.What precautions should I take while using Contrave?

It’s important to inform your healthcare provider about all medications you’re taking including over-the-counter medicines,pain medicines,blood sugar medication like sulfonylureas,and antidepressants.You should also mention if you have medical conditions like diabetes mellitus,type 2 diabetes mellitus,a history of drug abuse or heart attack,to ensure safety.

5.Can I just buy Contrave from any pharmacy in Glenview or Chicago?

Contrave is an FDA-approved medication but requires a prescription.So,you’ll need to consult with your healthcare provider.They will determine if it’s suitable for you based on your health status,functional medicine approach,and whether it fits into your overall weight loss plan.If prescribed,you can obtain it from pharmacies that accept insurance plans like Tricare,MEDICAID,MEDICARE Part D,but always check availability first.

6.How long do I need to take Contrave before seeing results?

Weight loss timing varies among individuals. Some might notice changes within the first few weeks, others may take longer. It’s crucial to follow the dosage instructions closely and maintain consistent communication with your healthcare provider regarding progress and any concerns. Consistency and patience play key roles in achieving effective results.