Is Hormone Replacement Therapy risky for Women?
On the contrary…
When women consider hormone replacement the looming question is about the risks, especially of breast cancer, strokes and heart attacks. On review, women are the most protected during their 30’s when they have the highest hormone levels. It is only after menopause that women have increased risk of stroke, heart attack and breast cancer. Data suggests that it is hormone imbalances that contribute to breast cancer. We know that, most breast cancers occur after menopause; precisely at the time when the ovaries stop producing the normal balance of hormones.
The science of Breast Cancer and Hormone decline explained –
First, progesterone, which prevents breast cell division, declines from the late 30’s. Second, approximately 10 years later comes an imbalance of the estrogens. Estriol (E3) , which is breast and clot protective, decreases from 80% to 10%. Estrone (E1), which is breast and clot stimulating, goes up from 10% to 80%. The increased E1 is undesirable as E1 is converted to forms of estrogen (i.e. 16-OH E1) which are mutagenic and carcinogenic to the breast. So, restoration of protective hormone levels needs to be considered a possible preventative step against breast cancer.
But what about the Women’s Health Initiative (WHI) study?
Large studies so far have used, synthetic, hormones (not identical to human hormones) with a ratio of estrogen weighted towards E1 like the large Women’s Health Initiative (WHI) study published in 2002, which was followed by much confusion.
Reanalysis of this study and many others has eventually led to the following three conclusions on hormone restoration in women.
Did you know that Testosterone is important for both males and females?
Testosterone declines in men and women from the late 30’s onwards producing loss of desire for sex, joint and bone pain, muscle weakness, loss of confidence, moodiness, depression, anxiety, muscle loss and fat gain. Testosterone restoration not only addresses these symptoms; but studies support a protective role for testosterone against heart disease, cognitive decline and bone loss.